منابع مشابه
Ancient origin of RNA editing in kinetoplastid protozoa.
A rooted phylogenetic tree of the kinetoplastid protozoa has been constructed that, together with a comparative analysis of editing of several genes, leads to the surprising conclusion that extensive or pan-editing with multiple overlapping guide RNAs is more ancient than 5'-editing. The mechanism of editing is still uncertain, but multiple ribonucleoprotein complexes have been identified that ...
متن کاملRNA editing and the mitochondrial cryptogenes of kinetoplastid protozoa.
The term “RNA editing” was initially introduced to describe a process resulting in the addition of nongenomitally encoded uridine residues (U’s) to mitochondrial mRNAs in the kinetoplastid protozoa (Benne et al., 1986), but has recently been used to describe other processes involving modification of RNA in other organisms (Powell et al., 1987; Chen et al., 1987; Thomas et al., 1988). We would l...
متن کاملSense from nonsense: RNA editing in mitochondria of kinetoplastid protozoa and slime molds
The reworking of the sequences of mitochondrial DNA transcripts is an intriguing genetic phenomenon that continues to create amazement even today, 9 years after the discovery of uridine (U) insertion/deletion editing in trypanosomatid mitochondria. Upon initial exposure to this phenomenon, the usual scientific questions of what and how were rapidly followed by the more philosophical question of...
متن کاملCharacterization of the apolipoprotein B mRNA editing enzyme: no similarity to the proposed mechanism of RNA editing in kinetoplastid protozoa
Intestinal apolipoprotein B mRNA is edited at nucleotide 6666 by a C to U transition resulting in a translational stop codon. The enzymatic properties of the editing activity were characterised in vitro using rat enterocyte cytosolic extract. The editing activity has no nucleotide or ion cofactor requirement. It shows substrate saturation with an apparent Km for the RNA substrate of 2.2 nM. The...
متن کاملProtein trafficking in kinetoplastid protozoa.
The kinetoplastid protozoa infect hosts ranging from invertebrates to plants and mammals, causing diseases of medical and economic importance. They are the earliest-branching organisms in eucaryotic evolution to have either mitochondria or peroxisome-like microbodies. Investigation of their protein trafficking enables us to identify characteristics that have been conserved throughout eucaryotic...
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ژورنال
عنوان ژورنال: Microbiology and Molecular Biology Reviews
سال: 1997
ISSN: 1092-2172,1098-5557
DOI: 10.1128/mmbr.61.1.105-120.1997